Ruthardt M - Search Results

1

Understanding a high-risk acute myeloid leukemia by analyzing the interactome of its major driver mutation.

Chiriches C, Nicolaisen N, Wieske M, Elhaddad H, Mehmetbeyoglu E, Alvares C, Becher D, Hole P, Ottmann OG, Ruthardt M. Chiriches C, et al. Among authors: ruthardt m. PLoS Genet. 2022 Oct 26;18(10):e1010463. doi: 10.1371/journal.pgen.1010463. eCollection 2022 Oct. PLoS Genet. 2022. PMID: 36288392 Free PMC article.

2

Activation of signaling pathways in models of t(6;9)-acute myeloid leukemia.

Chiriches C, Khan D, Wieske M, Guillen N, Rokicki M, Guy C, Wilson M, Heesom KJ, Ottmann OG, Ruthardt M. Chiriches C, et al. Among authors: ruthardt m. Ann Hematol. 2022 Oct;101(10):2179-2193. doi: 10.1007/s00277-022-04905-9. Epub 2022 Aug 8. Ann Hematol. 2022. PMID: 35941390 Free PMC article.

3

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia.

Rafiei A, Mian AA, Döring C, Metodieva A, Oancea C, Thalheimer FB, Hansmann ML, Ottmann OG, Ruthardt M. Rafiei A, et al. Among authors: ruthardt m. PLoS Genet. 2015 Apr 28;11(4):e1005144. doi: 10.1371/journal.pgen.1005144. eCollection 2015 Apr. PLoS Genet. 2015. PMID: 25919613 Free PMC article.

4

The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.

Puccetti E, Zheng X, Brambilla D, Seshire A, Beissert T, Boehrer S, Nürnberger H, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M. Puccetti E, et al. Among authors: ruthardt m. Cancer Res. 2005 Jul 15;65(14):6080-8. doi: 10.1158/0008-5472.CAN-04-3631. Cancer Res. 2005. PMID: 16024608

5

Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1^T315I and BCR-ABL1^T315I-E255K.

Mian AA, Haberbosch I, Khamaisie H, Agbarya A, Pietsch L, Eshel E, Najib D, Chiriches C, Ottmann OG, Hantschel O, Biondi RM, Ruthardt M, Mahajna J. Mian AA, et al. Among authors: ruthardt m. Ann Hematol. 2021 Aug;100(8):2023-2029. doi: 10.1007/s00277-020-04357-z. Epub 2021 Jun 10. Ann Hematol. 2021. PMID: 34110462 Free PMC article.

6

The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.

Mian AA, Schüll M, Zhao Z, Oancea C, Hundertmark A, Beissert T, Ottmann OG, Ruthardt M. Mian AA, et al. Among authors: ruthardt m. Leukemia. 2009 Sep;23(9):1614-21. doi: 10.1038/leu.2009.69. Epub 2009 Apr 16. Leukemia. 2009. PMID: 19369965

7

AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.

Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M. Puccetti E, et al. Among authors: ruthardt m. Cancer Res. 2002 Dec 1;62(23):7050-8. Cancer Res. 2002. PMID: 12460926

8

Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.

Bug G, Schwarz K, Schoch C, Kampfmann M, Henschler R, Hoelzer D, Ottmann OG, Ruthardt M. Bug G, et al. Among authors: ruthardt m. Haematologica. 2007 Apr;92(4):542-5. doi: 10.3324/haematol.10758. Haematologica. 2007. PMID: 17488665 Free article.

9

p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia.

Mian AA, Metodieva A, Najajreh Y, Ottmann OG, Mahajna J, Ruthardt M. Mian AA, et al. Among authors: ruthardt m. Haematologica. 2012 Feb;97(2):251-7. doi: 10.3324/haematol.2011.047191. Epub 2011 Nov 4. Haematologica. 2012. PMID: 22058195 Free PMC article.

10

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I.

Mian AA, Metodieva A, Badura S, Khateb M, Ruimi N, Najajreh Y, Ottmann OG, Mahajna J, Ruthardt M. Mian AA, et al. Among authors: ruthardt m. BMC Cancer. 2012 Sep 17;12:411. doi: 10.1186/1471-2407-12-411. BMC Cancer. 2012. PMID: 22985168 Free PMC article.

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