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The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Assad Kahn S, Costa SL, Gholamin S, Nitta RT, Dubois LG, Fève M, Zeniou M, Coelho PL, El-Habr E, Cadusseau J, Varlet P, Mitra SS, Devaux B, Kilhoffer MC, Cheshier SH, Moura-Neto V, Haiech J, Junier MP, Chneiweiss H. Assad Kahn S, et al. EMBO Mol Med. 2016 May 2;8(5):511-26. doi: 10.15252/emmm.201505421. Print 2016 May. EMBO Mol Med. 2016. PMID: 27138566 Free PMC article.
Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.
Zeniou M, Fève M, Mameri S, Dong J, Salomé C, Chen W, El-Habr EA, Bousson F, Sy M, Obszynski J, Boh A, Villa P, Assad Kahn S, Didier B, Bagnard D, Junier MP, Chneiweiss H, Haiech J, Hibert M, Kilhoffer MC. Zeniou M, et al. Among authors: assad kahn s. PLoS One. 2015 Aug 13;10(8):e0134793. doi: 10.1371/journal.pone.0134793. eCollection 2015. PLoS One. 2015. PMID: 26270679 Free PMC article.
Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling.
Dong J, Aulestia FJ, Assad Kahn S, Zeniou M, Dubois LG, El-Habr EA, Daubeuf F, Tounsi N, Cheshier SH, Frossard N, Junier MP, Chneiweiss H, Néant I, Moreau M, Leclerc C, Haiech J, Kilhoffer MC. Dong J, et al. Among authors: assad kahn s. Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1018-1027. doi: 10.1016/j.bbamcr.2017.01.010. Epub 2017 Jan 18. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28109792 Free article.
Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma.
Hutter G, Theruvath J, Graef CM, Zhang M, Schoen MK, Manz EM, Bennett ML, Olson A, Azad TD, Sinha R, Chan C, Assad Kahn S, Gholamin S, Wilson C, Grant G, He J, Weissman IL, Mitra SS, Cheshier SH. Hutter G, et al. Among authors: assad kahn s. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):997-1006. doi: 10.1073/pnas.1721434116. Epub 2019 Jan 2. Proc Natl Acad Sci U S A. 2019. PMID: 30602457 Free PMC article.
The availability of the embryonic TGF-β protein Nodal is dynamically regulated during glioblastoma multiforme tumorigenesis.
Oliveira-Nunes MC, Assad Kahn S, de Oliveira Barbeitas AL, E Spohr TC, Dubois LG, Ventura Matioszek GM, Querido W, Campanati L, de Brito Neto JM, Lima FR, Moura-Neto V, Carneiro K. Oliveira-Nunes MC, et al. Among authors: assad kahn s. Cancer Cell Int. 2016 Jun 17;16:46. doi: 10.1186/s12935-016-0324-3. eCollection 2016. Cancer Cell Int. 2016. PMID: 27330409 Free PMC article.
Antiproliferative activity of trans-avicennol from Zanthoxylum chiloperone var. angustifolium against human cancer stem cells.
Cebrián-Torrejón G, Assad Kahn S, Lagarde N, Castellano F, Leblanc K, Rodrigo J, Molinier-Frenkel V, Rojas de Arias A, Ferreira ME, Thirant C, Fournet A, Figadère B, Chneiweiss H, Poupon E. Cebrián-Torrejón G, et al. Among authors: assad kahn s. J Nat Prod. 2012 Feb 24;75(2):257-61. doi: 10.1021/np2004165. Epub 2012 Feb 3. J Nat Prod. 2012. PMID: 22304006