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Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging.
Cabral-Miranda F, Tamburini G, Martinez G, Ardiles AO, Medinas DB, Gerakis Y, Hung MD, Vidal R, Fuentealba M, Miedema T, Duran-Aniotz C, Diaz J, Ibaceta-Gonzalez C, Sabusap CM, Bermedo-Garcia F, Mujica P, Adamson S, Vitangcol K, Huerta H, Zhang X, Nakamura T, Sardi SP, Lipton SA, Kennedy BK, Henriquez JP, Cárdenas JC, Plate L, Palacios AG, Hetz C. Cabral-Miranda F, et al. EMBO J. 2022 Nov 17;41(22):e111952. doi: 10.15252/embj.2022111952. Epub 2022 Oct 31. EMBO J. 2022. PMID: 36314651 Free PMC article.
Endoplasmic reticulum proteostasis impairment in aging.
Martínez G, Duran-Aniotz C, Cabral-Miranda F, Vivar JP, Hetz C. Martínez G, et al. Aging Cell. 2017 Aug;16(4):615-623. doi: 10.1111/acel.12599. Epub 2017 Apr 23. Aging Cell. 2017. PMID: 28436203 Free PMC article. Review.
ER stress links aging to sporadic ALS.
Medinas DB, Cabral-Miranda F, Hetz C. Medinas DB, et al. Among authors: cabral miranda f. Aging (Albany NY). 2019 Jan 5;11(1):5-6. doi: 10.18632/aging.101705. Aging (Albany NY). 2019. PMID: 30612121 Free PMC article. No abstract available.
Proteostasis deregulation as a driver of C9ORF72 pathogenesis.
Torres P, Cabral-Miranda F, Gonzalez-Teuber V, Hetz C. Torres P, et al. Among authors: cabral miranda f. J Neurochem. 2021 Dec;159(6):941-957. doi: 10.1111/jnc.15529. Epub 2021 Nov 9. J Neurochem. 2021. PMID: 34679204 Free article. Review.
Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis.
Bilches Medinas D, Malik S, Yıldız-Bölükbaşı E, Borgonovo J, Saaranen MJ, Urra H, Pulgar E, Afzal M, Contreras D, Wright MT, Bodaleo F, Quiroz G, Rozas P, Mumtaz S, Díaz R, Rozas C, Cabral-Miranda F, Piña R, Valenzuela V, Uyan O, Reardon C, Woehlbier U, Brown RH, Sena-Esteves M, Gonzalez-Billault C, Morales B, Plate L, Ruddock LW, Concha ML, Hetz C, Tolun A. Bilches Medinas D, et al. Among authors: cabral miranda f. EMBO J. 2022 Dec 17;41(2):e105531. doi: 10.15252/embj.2020105531. Epub 2021 Dec 14. EMBO J. 2022. PMID: 34904718 Free PMC article.
The unfolded protein response transcription factor XBP1s ameliorates Alzheimer's disease by improving synaptic function and proteostasis.
Duran-Aniotz C, Poblete N, Rivera-Krstulovic C, Ardiles ÁO, Díaz-Hung ML, Tamburini G, Sabusap CMP, Gerakis Y, Cabral-Miranda F, Diaz J, Fuentealba M, Arriagada D, Muñoz E, Espinoza S, Martinez G, Quiroz G, Sardi P, Medinas DB, Contreras D, Piña R, Lourenco MV, Ribeiro FC, Ferreira ST, Rozas C, Morales B, Plate L, Gonzalez-Billault C, Palacios AG, Hetz C. Duran-Aniotz C, et al. Among authors: cabral miranda f. Mol Ther. 2023 Jul 5;31(7):2240-2256. doi: 10.1016/j.ymthe.2023.03.028. Epub 2023 Apr 4. Mol Ther. 2023. PMID: 37016577
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