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Page 1
An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor.
Reyes Gaido OE, Pavlaki N, Granger JM, Mesubi OO, Liu B, Lin BL, Long A, Walker D, Mayourian J, Schole KL, Terrillion CE, Nkashama LJ, Hulsurkar MM, Dorn LE, Ferrero KM, Huganir RL, Müller FU, Wehrens XHT, Liu JO, Luczak ED, Bezzerides VJ, Anderson ME. Reyes Gaido OE, et al. Sci Transl Med. 2023 Jun 21;15(701):eabq7839. doi: 10.1126/scitranslmed.abq7839. Epub 2023 Jun 21. Sci Transl Med. 2023. PMID: 37343080 Free PMC article.
Increased Reactive Oxygen Species-Mediated Ca2+/Calmodulin-Dependent Protein Kinase II Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome.
Liu X, Wang S, Guo X, Li Y, Ogurlu R, Lu F, Prondzynski M, de la Serna Buzon S, Ma Q, Zhang D, Wang G, Cotton J, Guo Y, Xiao L, Milan DJ, Xu Y, Schlame M, Bezzerides VJ, Pu WT. Liu X, et al. Circulation. 2021 May 11;143(19):1894-1911. doi: 10.1161/CIRCULATIONAHA.120.048698. Epub 2021 Apr 1. Circulation. 2021. PMID: 33793303 Free PMC article.
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
Konstantinidis K, Bezzerides VJ, Lai L, Isbell HM, Wei AC, Wu Y, Viswanathan MC, Blum ID, Granger JM, Heims-Waldron D, Zhang D, Luczak ED, Murphy KR, Lu F, Gratz DH, Manta B, Wang Q, Wang Q, Kolodkin AL, Gladyshev VN, Hund TJ, Pu WT, Wu MN, Cammarato A, Bianchet MA, Shea MA, Levine RL, Anderson ME. Konstantinidis K, et al. J Clin Invest. 2020 Sep 1;130(9):4663-4678. doi: 10.1172/JCI133181. J Clin Invest. 2020. PMID: 32749237 Free PMC article.
Gene therapy for inherited arrhythmias.
Bezzerides VJ, Prondzynski M, Carrier L, Pu WT. Bezzerides VJ, et al. Cardiovasc Res. 2020 Jul 15;116(9):1635-1650. doi: 10.1093/cvr/cvaa107. Cardiovasc Res. 2020. PMID: 32321160 Free PMC article. Review.
Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence.
Garbern JC, Helman A, Sereda R, Sarikhani M, Ahmed A, Escalante GO, Ogurlu R, Kim SL, Zimmerman JF, Cho A, MacQueen L, Bezzerides VJ, Parker KK, Melton DA, Lee RT. Garbern JC, et al. Circulation. 2020 Jan 28;141(4):285-300. doi: 10.1161/CIRCULATIONAHA.119.044205. Epub 2019 Nov 11. Circulation. 2020. PMID: 31707831 Free PMC article.