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Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa.
Renau TE, Léger R, Filonova L, Flamme EM, Wang M, Yen R, Madsen D, Griffith D, Chamberland S, Dudley MN, Lee VJ, Lomovskaya O, Watkins WJ, Ohta T, Nakayama K, Ishida Y. Renau TE, et al. Among authors: lee vj. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2755-8. doi: 10.1016/s0960-894x(03)00556-0. Bioorg Med Chem Lett. 2003. PMID: 12873508
Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy.
Lomovskaya O, Warren MS, Lee A, Galazzo J, Fronko R, Lee M, Blais J, Cho D, Chamberland S, Renau T, Leger R, Hecker S, Watkins W, Hoshino K, Ishida H, Lee VJ. Lomovskaya O, et al. Among authors: lee vj, lee m, lee a. Antimicrob Agents Chemother. 2001 Jan;45(1):105-16. doi: 10.1128/AAC.45.1.105-116.2001. Antimicrob Agents Chemother. 2001. PMID: 11120952 Free PMC article.
MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: discovery and early strategies for lead optimization.
Nakayama K, Ishida Y, Ohtsuka M, Kawato H, Yoshida Ki, Yokomizo Y, Hosono S, Ohta T, Hoshino K, Ishida H, Yoshida K, Renau TE, Léger R, Zhang JZ, Lee VJ, Watkins WJ. Nakayama K, et al. Among authors: lee vj. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4201-4. doi: 10.1016/j.bmcl.2003.07.024. Bioorg Med Chem Lett. 2003. PMID: 14623001
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds.
Nakayama K, Ishida Y, Ohtsuka M, Kawato H, Yoshida K, Yokomizo Y, Ohta T, Hoshino K, Otani T, Kurosaka Y, Yoshida K, Ishida H, Lee VJ, Renau TE, Watkins WJ. Nakayama K, et al. Among authors: lee vj. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4205-8. doi: 10.1016/j.bmcl.2003.07.027. Bioorg Med Chem Lett. 2003. PMID: 14623002
209 results