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Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3β.
Cociorva OM, Li B, Nomanbhoy T, Li Q, Nakamura A, Nakamura K, Nomura M, Okada K, Seto S, Yumoto K, Liyanage M, Zhang MC, Aban A, Leen B, Szardenings AK, Rosenblum JS, Kozarich JW, Kohno Y, Shreder KR. Cociorva OM, et al. Among authors: li q, li b. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5948-51. doi: 10.1016/j.bmcl.2011.07.073. Epub 2011 Aug 5. Bioorg Med Chem Lett. 2011. PMID: 21873061
6-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3β: discovery of nitrile derivatives with picomolar potency.
Li B, Cociorva OM, Nomanbhoy T, Li Q, Nakamura K, Nomura M, Okada K, Yumoto K, Liyanage M, Zhang MC, Aban A, Szardenings AK, Kozarich JW, Kohno Y, Shreder KR. Li B, et al. Among authors: li q. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1005-8. doi: 10.1016/j.bmcl.2011.12.006. Epub 2011 Dec 8. Bioorg Med Chem Lett. 2012. PMID: 22202172
ERK5 kinase activity is dispensable for cellular immune response and proliferation.
Lin EC, Amantea CM, Nomanbhoy TK, Weissig H, Ishiyama J, Hu Y, Sidique S, Li B, Kozarich JW, Rosenblum JS. Lin EC, et al. Among authors: li b. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11865-11870. doi: 10.1073/pnas.1609019113. Epub 2016 Sep 27. Proc Natl Acad Sci U S A. 2016. PMID: 27679845 Free PMC article.
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