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Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.
Bou G, Santillana E, Sheri A, Beceiro A, Sampson JM, Kalp M, Bethel CR, Distler AM, Drawz SM, Pagadala SR, van den Akker F, Bonomo RA, Romero A, Buynak JD. Bou G, et al. Among authors: pagadala sr. J Am Chem Soc. 2010 Sep 29;132(38):13320-31. doi: 10.1021/ja104092z. J Am Chem Soc. 2010. PMID: 20822105 Free PMC article.
Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.
Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD, Bonomo RA. Pattanaik P, et al. Among authors: pagadala sr. J Biol Chem. 2009 Jan 9;284(2):945-53. doi: 10.1074/jbc.M806833200. Epub 2008 Oct 27. J Biol Chem. 2009. PMID: 18955486 Free PMC article.
Penicillin sulfone inhibitors of class D beta-lactamases.
Drawz SM, Bethel CR, Doppalapudi VR, Sheri A, Pagadala SR, Hujer AM, Skalweit MJ, Anderson VE, Chen SG, Buynak JD, Bonomo RA. Drawz SM, et al. Among authors: pagadala sr. Antimicrob Agents Chemother. 2010 Apr;54(4):1414-24. doi: 10.1128/AAC.00743-09. Epub 2010 Jan 19. Antimicrob Agents Chemother. 2010. PMID: 20086146 Free PMC article.