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The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC. Skaletsky H, et al. Among authors: pyntikova t. Nature. 2003 Jun 19;423(6942):825-37. doi: 10.1038/nature01722. Nature. 2003. PMID: 12815422
Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content.
Hughes JF, Skaletsky H, Pyntikova T, Graves TA, van Daalen SK, Minx PJ, Fulton RS, McGrath SD, Locke DP, Friedman C, Trask BJ, Mardis ER, Warren WC, Repping S, Rozen S, Wilson RK, Page DC. Hughes JF, et al. Among authors: pyntikova t. Nature. 2010 Jan 28;463(7280):536-9. doi: 10.1038/nature08700. Epub 2010 Jan 13. Nature. 2010. PMID: 20072128 Free PMC article.
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes.
Hughes JF, Skaletsky H, Brown LG, Pyntikova T, Graves T, Fulton RS, Dugan S, Ding Y, Buhay CJ, Kremitzki C, Wang Q, Shen H, Holder M, Villasana D, Nazareth LV, Cree A, Courtney L, Veizer J, Kotkiewicz H, Cho TJ, Koutseva N, Rozen S, Muzny DM, Warren WC, Gibbs RA, Wilson RK, Page DC. Hughes JF, et al. Among authors: pyntikova t. Nature. 2012 Feb 22;483(7387):82-6. doi: 10.1038/nature10843. Nature. 2012. PMID: 22367542 Free PMC article.
TALEN-mediated editing of the mouse Y chromosome.
Wang H, Hu YC, Markoulaki S, Welstead GG, Cheng AW, Shivalila CS, Pyntikova T, Dadon DB, Voytas DF, Bogdanove AJ, Page DC, Jaenisch R. Wang H, et al. Among authors: pyntikova t. Nat Biotechnol. 2013 Jun;31(6):530-2. doi: 10.1038/nbt.2595. Epub 2013 May 12. Nat Biotechnol. 2013. PMID: 23666012 Free PMC article.
Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators.
Bellott DW, Hughes JF, Skaletsky H, Brown LG, Pyntikova T, Cho TJ, Koutseva N, Zaghlul S, Graves T, Rock S, Kremitzki C, Fulton RS, Dugan S, Ding Y, Morton D, Khan Z, Lewis L, Buhay C, Wang Q, Watt J, Holder M, Lee S, Nazareth L, Alföldi J, Rozen S, Muzny DM, Warren WC, Gibbs RA, Wilson RK, Page DC. Bellott DW, et al. Among authors: pyntikova t. Nature. 2014 Apr 24;508(7497):494-9. doi: 10.1038/nature13206. Nature. 2014. PMID: 24759411 Free PMC article.
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