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Year Number of Results
2013 1
2014 3
2015 4
2016 5
2017 8
2018 7
2019 9
2020 4
2021 2
2022 1
2024 0

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38 results

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Page 1
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.
Su W, Mukherjee R, Yaeger R, Son J, Xu J, Na N, Merna Timaul N, Hechtman J, Paroder V, Lin M, Mattar M, Qiu J, Chang Q, Zhao H, Zhang J, Little M, Adachi Y, Han SW, Taylor BS, Ebi H, Abdel-Wahab O, de Stanchina E, Rudin CM, Jänne PA, McCormick F, Yao Z, Rosen N. Su W, et al. Mol Cell. 2022 Jul 7;82(13):2443-2457.e7. doi: 10.1016/j.molcel.2022.04.034. Epub 2022 May 24. Mol Cell. 2022. PMID: 35613620 Free PMC article.
Safety and activity of selinexor in patients with myelodysplastic syndromes or oligoblastic acute myeloid leukaemia refractory to hypomethylating agents: a single-centre, single-arm, phase 2 trial.
Taylor J, Mi X, Penson AV, Paffenholz SV, Alvarez K, Sigler A, Chung SS, Rampal RK, Park JH, Stein EM, Tallman MS, Sen F, Gönen M, Abdel-Wahab O, Klimek VM. Taylor J, et al. Lancet Haematol. 2020 Aug;7(8):e566-e574. doi: 10.1016/S2352-3026(20)30209-X. Lancet Haematol. 2020. PMID: 32735836 Free PMC article. Clinical Trial.
Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer.
Hanrahan AJ, Sylvester BE, Chang MT, Elzein A, Gao J, Han W, Liu Y, Xu D, Gao SP, Gorelick AN, Jones AM, Kiliti AJ, Nissan MH, Nimura CA, Poteshman AN, Yao Z, Gao Y, Hu W, Wise HC, Gavrila EI, Shoushtari AN, Tiwari S, Viale A, Abdel-Wahab O, Merghoub T, Berger MF, Rosen N, Taylor BS, Solit DB. Hanrahan AJ, et al. Cancer Res. 2020 Oct 1;80(19):4233-4243. doi: 10.1158/0008-5472.CAN-20-0865. Epub 2020 Jul 8. Cancer Res. 2020. PMID: 32641410 Free PMC article.
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.
Durham BH, Lopez Rodrigo E, Picarsic J, Abramson D, Rotemberg V, De Munck S, Pannecoucke E, Lu SX, Pastore A, Yoshimi A, Mandelker D, Ceyhan-Birsoy O, Ulaner GA, Walsh M, Yabe M, Petrova-Drus K, Arcila ME, Ladanyi M, Solit DB, Berger MF, Hyman DM, Lacouture ME, Erickson C, Saganty R, Ki M, Dunkel IJ, Santa-María López V, Mora J, Haroche J, Emile JF, Decaux O, Geissmann F, Savvides SN, Drilon A, Diamond EL, Abdel-Wahab O. Durham BH, et al. Nat Med. 2019 Dec;25(12):1839-1842. doi: 10.1038/s41591-019-0653-6. Epub 2019 Nov 25. Nat Med. 2019. PMID: 31768065 Free PMC article.
PTEN isoforms with dual and opposing function.
Taylor J, Abdel-Wahab O. Taylor J, et al. Nat Cell Biol. 2019 Nov;21(11):1306-1308. doi: 10.1038/s41556-019-0405-3. Nat Cell Biol. 2019. PMID: 31685989 Free PMC article.
Altered RNA Processing in Cancer Pathogenesis and Therapy.
Obeng EA, Stewart C, Abdel-Wahab O. Obeng EA, et al. Cancer Discov. 2019 Nov;9(11):1493-1510. doi: 10.1158/2159-8290.CD-19-0399. Epub 2019 Oct 14. Cancer Discov. 2019. PMID: 31611195 Free PMC article. Review.
Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.
Fong JY, Pignata L, Goy PA, Kawabata KC, Lee SC, Koh CM, Musiani D, Massignani E, Kotini AG, Penson A, Wun CM, Shen Y, Schwarz M, Low DH, Rialdi A, Ki M, Wollmann H, Mzoughi S, Gay F, Thompson C, Hart T, Barbash O, Luciani GM, Szewczyk MM, Wouters BJ, Delwel R, Papapetrou EP, Barsyte-Lovejoy D, Arrowsmith CH, Minden MD, Jin J, Melnick A, Bonaldi T, Abdel-Wahab O, Guccione E. Fong JY, et al. Cancer Cell. 2019 Aug 12;36(2):194-209.e9. doi: 10.1016/j.ccell.2019.07.003. Cancer Cell. 2019. PMID: 31408619 Free PMC article.
38 results