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Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold.
Stallings WC, Abdel-Meguid SS, Lim LW, Shieh HS, Dayringer HE, Leimgruber NK, Stegeman RA, Anderson KS, Sikorski JA, Padgette SR, Kishore GM. Stallings WC, et al. Among authors: shieh hs. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):5046-50. doi: 10.1073/pnas.88.11.5046. Proc Natl Acad Sci U S A. 1991. PMID: 11607190 Free PMC article.
Three-dimensional structure of human cytomegalovirus protease.
Shieh HS, Kurumbail RG, Stevens AM, Stegeman RA, Sturman EJ, Pak JY, Wittwer AJ, Palmier MO, Wiegand RC, Holwerda BC, Stallings WC. Shieh HS, et al. Nature. 1996 Sep 19;383(6597):279-82. doi: 10.1038/383279a0. Nature. 1996. PMID: 8805708
Using sampling techniques in protein crystallization.
Shieh HS, Stallings WC, Stevens AM, Stegeman RA. Shieh HS, et al. Acta Crystallogr D Biol Crystallogr. 1995 May 1;51(Pt 3):305-10. doi: 10.1107/S0907444994011728. Acta Crystallogr D Biol Crystallogr. 1995. PMID: 15299296
Synthesis and activity of selective MMP inhibitors with an aryl backbone.
Barta TE, Becker DP, Bedell LJ, De Crescenzo GA, McDonald JJ, Munie GE, Rao S, Shieh HS, Stegeman R, Stevens AM, Villamil CI. Barta TE, et al. Among authors: shieh hs. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2815-7. doi: 10.1016/s0960-894x(00)00584-9. Bioorg Med Chem Lett. 2000. PMID: 11133099
Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis.
Ruminski PG, Massa M, Strohbach J, Hanau CE, Schmidt M, Scholten JA, Fletcher TR, Hamper BC, Carroll JN, Shieh HS, Caspers N, Collins B, Grapperhaus M, Palmquist KE, Collins J, Baldus JE, Hitchcock J, Kleine HP, Rogers MD, McDonald J, Munie GE, Messing DM, Portolan S, Whiteley LO, Sunyer T, Schnute ME. Ruminski PG, et al. Among authors: shieh hs. J Med Chem. 2016 Jan 14;59(1):313-27. doi: 10.1021/acs.jmedchem.5b01434. Epub 2015 Dec 24. J Med Chem. 2016. PMID: 26653735
49 results