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The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β 2-adrenoceptor agonist in preclinical animal species.
Salmon M, Tannheimer SL, Gentzler TT, Cui ZH, Sorensen EA, Hartsough KC, Kim M, Purvis LJ, Barrett EG, McDonald JD, Rudolph K, Doyle-Eisele M, Kuehl PJ, Royer CM, Baker WR, Phillips GB, Wright CD. Salmon M, et al. Among authors: tannheimer sl. Pharmacol Res Perspect. 2014 Aug;2(4):e00046. doi: 10.1002/prp2.46. Epub 2014 Jun 9. Pharmacol Res Perspect. 2014. PMID: 25505595 Free PMC article.
GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells.
Joshi T, Yan D, Hamed O, Tannheimer SL, Phillips GB, Wright CD, Kim M, Salmon M, Newton R, Giembycz MA. Joshi T, et al. Among authors: tannheimer sl. J Pharmacol Exp Ther. 2017 Feb;360(2):324-340. doi: 10.1124/jpet.116.237743. Epub 2016 Dec 7. J Pharmacol Exp Ther. 2017. PMID: 27927912
The receptor of the colony-stimulating factor-1 (CSF-1R) is a novel prognostic factor and therapeutic target in follicular lymphoma.
Valero JG, Matas-Céspedes A, Arenas F, Rodriguez V, Carreras J, Serrat N, Guerrero-Hernández M, Yahiaoui A, Balagué O, Martin S, Capdevila C, Hernández L, Magnano L, Rivas-Delgado A, Tannheimer S, Cid MC, Campo E, López-Guillermo A, Colomer D, Pérez-Galán P. Valero JG, et al. Leukemia. 2021 Sep;35(9):2635-2649. doi: 10.1038/s41375-021-01201-9. Epub 2021 Mar 17. Leukemia. 2021. PMID: 33731849 Free PMC article.
Integrated genomic characterization of IDH1-mutant glioma malignant progression.
Bai H, Harmancı AS, Erson-Omay EZ, Li J, Coşkun S, Simon M, Krischek B, Özduman K, Omay SB, Sorensen EA, Turcan Ş, Bakırcığlu M, Carrión-Grant G, Murray PB, Clark VE, Ercan-Sencicek AG, Knight J, Sencar L, Altınok S, Kaulen LD, Gülez B, Timmer M, Schramm J, Mishra-Gorur K, Henegariu O, Moliterno J, Louvi A, Chan TA, Tannheimer SL, Pamir MN, Vortmeyer AO, Bilguvar K, Yasuno K, Günel M. Bai H, et al. Among authors: tannheimer sl. Nat Genet. 2016 Jan;48(1):59-66. doi: 10.1038/ng.3457. Epub 2015 Nov 30. Nat Genet. 2016. PMID: 26618343 Free PMC article.
PI3Kδ inhibition reshapes follicular lymphoma-immune microenvironment cross talk and unleashes the activity of venetoclax.
Serrat N, Guerrero-Hernández M, Matas-Céspedes A, Yahiaoui A, Valero JG, Nadeu F, Clot G, Di Re M, Corbera-Bellalta M, Magnano L, Rivas-Delgado A, Enjuanes A, Beà S, Cid MC, Campo E, Montero J, Hodson DJ, López-Guillermo A, Colomer D, Tannheimer S, Pérez-Galán P. Serrat N, et al. Blood Adv. 2020 Sep 8;4(17):4217-4231. doi: 10.1182/bloodadvances.2020001584. Blood Adv. 2020. PMID: 32898249 Free PMC article.
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