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The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor.
Chen KT, Hour MJ, Tsai SC, Chung JG, Kuo SC, Lu CC, Chiu YJ, Chuang YH, Yang JS. Chen KT, et al. Among authors: tsai sc. Int J Oncol. 2011 Sep;39(3):611-9. doi: 10.3892/ijo.2011.1071. Epub 2011 Jun 8. Int J Oncol. 2011. PMID: 21667022
The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells.
Cheng YY, Yang JS, Tsai SC, Liaw CC, Chung JG, Huang LJ, Lee KH, Lu CC, Chien HC, Tsuzuki M, Kuo SC. Cheng YY, et al. Among authors: tsai sc. Oncol Rep. 2012 Oct;28(4):1482-90. doi: 10.3892/or.2012.1923. Epub 2012 Jul 19. Oncol Rep. 2012. PMID: 22825350
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