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Structural basis for (p)ppGpp-mediated inhibition of the GTPase RbgA.
Pausch P, Steinchen W, Wieland M, Klaus T, Freibert SA, Altegoer F, Wilson DN, Bange G. Pausch P, et al. Among authors: wilson dn. J Biol Chem. 2018 Dec 21;293(51):19699-19709. doi: 10.1074/jbc.RA118.003070. Epub 2018 Oct 26. J Biol Chem. 2018. PMID: 30366986 Free PMC article.
The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis.
Schäfer H, Beckert B, Frese CK, Steinchen W, Nuss AM, Beckstette M, Hantke I, Driller K, Sudzinová P, Krásný L, Kaever V, Dersch P, Bange G, Wilson DN, Turgay K. Schäfer H, et al. Among authors: wilson dn. PLoS Genet. 2020 Mar 16;16(3):e1008275. doi: 10.1371/journal.pgen.1008275. eCollection 2020 Mar. PLoS Genet. 2020. PMID: 32176689 Free PMC article.
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.
Osterman IA, Wieland M, Maviza TP, Lashkevich KA, Lukianov DA, Komarova ES, Zakalyukina YV, Buschauer R, Shiriaev DI, Leyn SA, Zlamal JE, Biryukov MV, Skvortsov DA, Tashlitsky VN, Polshakov VI, Cheng J, Polikanov YS, Bogdanov AA, Osterman AL, Dmitriev SE, Beckmann R, Dontsova OA, Wilson DN, Sergiev PV. Osterman IA, et al. Among authors: wilson dn. Nat Chem Biol. 2020 Oct;16(10):1071-1077. doi: 10.1038/s41589-020-0578-x. Epub 2020 Jun 29. Nat Chem Biol. 2020. PMID: 32601485
Bifunctional Nitrone-Conjugated Secondary Metabolite Targeting the Ribosome.
Limbrick EM, Graf M, Derewacz DK, Nguyen F, Spraggins JM, Wieland M, Ynigez-Gutierrez AE, Reisman BJ, Zinshteyn B, McCulloch KM, Iverson TM, Green R, Wilson DN, Bachmann BO. Limbrick EM, et al. Among authors: wilson dn. J Am Chem Soc. 2020 Oct 28;142(43):18369-18377. doi: 10.1021/jacs.0c04675. Epub 2020 Oct 19. J Am Chem Soc. 2020. PMID: 32709196 Free PMC article.
The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Wieland M, Holm M, Rundlet EJ, Morici M, Koller TO, Maviza TP, Pogorevc D, Osterman IA, Müller R, Blanchard SC, Wilson DN. Wieland M, et al. Among authors: wilson dn. Proc Natl Acad Sci U S A. 2022 May 10;119(19):e2114214119. doi: 10.1073/pnas.2114214119. Epub 2022 May 2. Proc Natl Acad Sci U S A. 2022. PMID: 35500116 Free PMC article.
188 results