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Page 1
Spermidine in health and disease.
Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Madeo F, et al. Science. 2018 Jan 26;359(6374):eaan2788. doi: 10.1126/science.aan2788. Science. 2018. PMID: 29371440 Review.
Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related mortality in human epidemiological studies. Spermidine preserves mitochondrial function, exhibits anti-inflammatory properties, and prevents stem cell senescence. Mechanistically, …
Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related mortality in human epidemiological studies. …
Mechanisms of spermidine-induced autophagy and geroprotection.
Hofer SJ, Simon AK, Bergmann M, Eisenberg T, Kroemer G, Madeo F. Hofer SJ, et al. Nat Aging. 2022 Dec;2(12):1112-1129. doi: 10.1038/s43587-022-00322-9. Epub 2022 Dec 22. Nat Aging. 2022. PMID: 37118547 Review.
In mice, it also postpones the manifestation of various age-associated disorders such as cardiovascular disease and neurodegeneration. The specific features of spermidine, including its presence in common food items, make it an interesting candidate for translational aging …
In mice, it also postpones the manifestation of various age-associated disorders such as cardiovascular disease and neurodegeneration. The s …
Spermidine as a target for cancer therapy.
Fan J, Feng Z, Chen N. Fan J, et al. Pharmacol Res. 2020 Sep;159:104943. doi: 10.1016/j.phrs.2020.104943. Epub 2020 May 24. Pharmacol Res. 2020. PMID: 32461185 Review.
Spermidine, as a natural component from polyamine members, is originally isolated from semen and also existed in many natural plants, and can be responsible for cell growth and development in eukaryotes. The supplementation of spermidine can extend health and lifesp …
Spermidine, as a natural component from polyamine members, is originally isolated from semen and also existed in many natural plants, …
Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.
Xu TT, Li H, Dai Z, Lau GK, Li BY, Zhu WL, Liu XQ, Liu HF, Cai WW, Huang SQ, Wang Q, Zhang SJ. Xu TT, et al. Aging (Albany NY). 2020 Apr 8;12(7):6401-6414. doi: 10.18632/aging.103035. Epub 2020 Apr 8. Aging (Albany NY). 2020. PMID: 32268299 Free PMC article.
The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. ...Spermidine and spermine phosphorylate AMPK and regulate autophagy proteins (LC3, Beclin 1 and p62). ...
The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. ...Spermidine …
A comprehensive review of spermidine: Safety, health effects, absorption and metabolism, food materials evaluation, physical and chemical processing, and bioprocessing.
Zou D, Zhao Z, Li L, Min Y, Zhang D, Ji A, Jiang C, Wei X, Wu X. Zou D, et al. Compr Rev Food Sci Food Saf. 2022 May;21(3):2820-2842. doi: 10.1111/1541-4337.12963. Epub 2022 Apr 27. Compr Rev Food Sci Food Saf. 2022. PMID: 35478379 Review.
In particular, the core metabolic pathways, key gene targets, and efficient metabolic engineering strategies involved in the biosynthesis of spermidine and its precursors were discussed. Moreover, limitations and future perspectives of spermidine research were propo …
In particular, the core metabolic pathways, key gene targets, and efficient metabolic engineering strategies involved in the biosynthesis of …
Spermidine inhibits vascular calcification in chronic kidney disease through modulation of SIRT1 signaling pathway.
Liu X, Chen A, Liang Q, Yang X, Dong Q, Fu M, Wang S, Li Y, Ye Y, Lan Z, Chen Y, Ou JS, Yang P, Lu L, Yan J. Liu X, et al. Aging Cell. 2021 Jun;20(6):e13377. doi: 10.1111/acel.13377. Epub 2021 May 9. Aging Cell. 2021. PMID: 33969611 Free PMC article.
Additionally, western blot analysis revealed that spermidine treatment inhibited osteogenic differentiation of rat and human VSMCs. ...Both pharmacological inhibition of SIRT1 by SIRT1 inhibitor EX527 and knockdown of SIRT1 by siRNA markedly blocked the inhibitory effect o …
Additionally, western blot analysis revealed that spermidine treatment inhibited osteogenic differentiation of rat and human VSMCs. . …
Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.
Schwarz C, Benson GS, Horn N, Wurdack K, Grittner U, Schilling R, Märschenz S, Köbe T, Hofer SJ, Magnes C, Stekovic S, Eisenberg T, Sigrist SJ, Schmitz D, Wirth M, Madeo F, Flöel A. Schwarz C, et al. JAMA Netw Open. 2022 May 2;5(5):e2213875. doi: 10.1001/jamanetworkopen.2022.13875. JAMA Netw Open. 2022. PMID: 35616942 Free PMC article. Clinical Trial.
OBJECTIVE: To determine the effect of longer-term spermidine supplementation on memory performance and biomarkers in this at-risk group. ...INTERVENTIONS: One hundred participants were randomly assigned (1:1 ratio) to 12 months of dietary supplementation with either a s …
OBJECTIVE: To determine the effect of longer-term spermidine supplementation on memory performance and biomarkers in this at-risk gro …
Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders.
Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M. Ghosh I, et al. Neuropeptides. 2020 Oct;83:102083. doi: 10.1016/j.npep.2020.102083. Epub 2020 Aug 24. Neuropeptides. 2020. PMID: 32873420 Review.
Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. ...Exogenously administered spermidine helps in the treatment of brain diseases. Further, current studies highlight the ability of spermidine to promote longevity by …
Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. ...Exogenously administered spermidi …
The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses.
Shi YJ, Zhang J, Wang YW, Ding K, Yan Y, Xia CY, Li XX, He J, Zhang WK, Xu JK. Shi YJ, et al. Eur J Med Chem. 2022 Oct 5;240:114600. doi: 10.1016/j.ejmech.2022.114600. Epub 2022 Jul 9. Eur J Med Chem. 2022. PMID: 35863273 Review.
Spermidine alkaloids are a kind of natural products possessing an aliphatic triamine structure with three or four methylene groups between two N-atoms. ...This will help to open up new pharmacological investigation fields and better drug design based on these spermidine …
Spermidine alkaloids are a kind of natural products possessing an aliphatic triamine structure with three or four methylene groups be …
Spermidine: a novel autophagy inducer and longevity elixir.
Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G. Madeo F, et al. Autophagy. 2010 Jan;6(1):160-2. doi: 10.4161/auto.6.1.10600. Autophagy. 2010. PMID: 20110777 Review.
Spermidine is a ubiquitous polycation that is synthesized from putrescine and serves as a precursor of spermine. ...Spermidine induces autophagy in cultured yeast and mammalian cells, as well as in nematodes and flies. ...
Spermidine is a ubiquitous polycation that is synthesized from putrescine and serves as a precursor of spermine. ...Spermidine …
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