Chromosomal mapping of five mouse G protein gamma subunits

Genomics. 1999 Apr 1;57(1):173-6. doi: 10.1006/geno.1999.5763.


Heterotrimeric G proteins, composed of alpha, beta, and gamma subunits, transduce signals from transmembrane receptors to a wide range of intracellular effectors. The G protein gamma subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Using an interspecific backcross panel, we have determined the mouse chromosomal locations of five gamma subunit genes: gamma2, gamma8, gamma10, gamma12, and gammaCone. Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • GTP-Binding Proteins / genetics*
  • Humans
  • Inbreeding
  • Mice
  • Models, Genetic
  • Molecular Sequence Data
  • Polymorphism, Restriction Fragment Length


  • GTP-Binding Proteins

Associated data

  • GENBANK/AF098487
  • GENBANK/AF098488
  • GENBANK/AF098489
  • GENBANK/AH007445