Topological characteristics of helical repeat proteins

Curr Opin Struct Biol. 1999 Jun;9(3):383-9. doi: 10.1016/s0959-440x(99)80052-9.


The recent elucidation of protein structures based upon repeating amino acid motifs, including the armadillo motif, the HEAT motif and tetratricopeptide repeats, reveals that they belong to the class of helical repeat proteins. These proteins share the common property of being assembled from tandem repeats of an alpha-helical structural unit, creating extended superhelical structures that are ideally suited to create a protein recognition interface.

Publication types

  • Review

MeSH terms

  • Animals
  • Conserved Sequence
  • Models, Molecular
  • Protein Structure, Secondary
  • Proteins / chemistry*
  • Repetitive Sequences, Amino Acid*


  • Proteins