Large-scale chromatin structure and function

Curr Opin Cell Biol. 1999 Jun;11(3):307-11. doi: 10.1016/S0955-0674(99)80041-6.


Recent results in living cells have now established the existence of levels of chromatin folding above the 30 nm fiber within interphase chromosomes. We discuss the potential functional impact of this large-scale chromatin organization, including its possible role in regulating gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromatin / chemistry
  • Chromatin / genetics
  • Chromatin / physiology*
  • Gene Expression Regulation
  • Humans
  • Interphase
  • Molecular Conformation


  • Chromatin