Extrapyramidal side-effects from droperidol mixed with morphine for patient-controlled analgesia in two children

Paediatr Anaesth. 1999;9(4):362-4. doi: 10.1046/j.1460-9592.1999.00347.x.

Abstract

We report two cases of extrapyramidal reactions occurring in children following the use of droperidol in combination with morphine for patient-controlled analgesia (PCA). Symptoms appeared 38 and 27 h, respectively, after commencement and after a total dose of 0.14 mg.kg-1 and 0.17 mg.kg-1, respectively. Although effective and safe in adult patients, we recommend caution with the use of droperidol-morphine mixtures for PCA in paediatric patients.

Publication types

  • Case Reports

MeSH terms

  • Analgesia, Patient-Controlled / adverse effects*
  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / adverse effects*
  • Appendectomy
  • Basal Ganglia Diseases / chemically induced*
  • Basal Ganglia Diseases / drug therapy
  • Benztropine / administration & dosage
  • Benztropine / therapeutic use
  • Child
  • Dopamine Antagonists / administration & dosage
  • Dopamine Antagonists / adverse effects*
  • Dopamine Uptake Inhibitors / administration & dosage
  • Dopamine Uptake Inhibitors / therapeutic use
  • Droperidol / administration & dosage
  • Droperidol / adverse effects*
  • Drug Combinations
  • Female
  • Humans
  • Morphine / administration & dosage
  • Morphine / adverse effects*
  • Pain, Postoperative / prevention & control
  • Paralysis / chemically induced
  • Paralysis / drug therapy
  • Time Factors
  • Ureter / surgery

Substances

  • Analgesics, Opioid
  • Dopamine Antagonists
  • Dopamine Uptake Inhibitors
  • Drug Combinations
  • Benztropine
  • Morphine
  • Droperidol