Our experience on the association of a new physical and medical therapy in patients suffering from induratio penis plastica

Eur Urol. 1999 Oct;36(4):327-30. doi: 10.1159/000020013.


Objectives: To check the efficiency of shock waves in the treatment of induratio penis plastica. The Minilith SL1, successfully used in orthopedic or salivary stones because of its lithotriptic power, can be used to break plaques in Peyronie's disease.

Methods: A total of 130 patients affected with Peyronie's disease were entered into a prospective trial. Patients with completely calcified plaques as determined by ultrasound evaluation were excluded. We divided the patients into three treatment groups: (A) shock waves alone in 21 patients; (B) a combination of shock waves and verapamil (perilesional injection) in 36 patients, and (C) verapamil alone in 73 patients. First, we treated all groups A and B patients 3 times, 20 min each time, with a Minilith SL1, and then only the patients of the second group received a complete cycle of twelve injections of verapamil (10 mg) every 2 weeks for 6 months. The group of 73 patients (group C) treated during the previous 2 years with a medical therapy (only injection of verapamil) was used as a control group.

Results: Ultrasound evaluation showed a reduction of plaque in 11/21 group A patients and 7/36 group B patients. The treatment was tolerated very well and only 11 petechiae in some patients were noticed after ESW treatment.

Conclusions: The therapeutic association of shock waves with verapamil injection is an effective nonoperative treatment for the stabilization of Peyronie's disease.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Erectile Dysfunction / drug therapy
  • Erectile Dysfunction / therapy
  • High-Energy Shock Waves / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Patient Satisfaction
  • Penile Induration / diagnostic imaging
  • Penile Induration / drug therapy
  • Penile Induration / therapy*
  • Prospective Studies
  • Ultrasonography
  • Verapamil / therapeutic use*


  • Verapamil