Total hypotrichosis: genetic form of alopecia not linked to hairless gene

Lancet. 1999 Sep 25;354(9184):1097-8. doi: 10.1016/s0140-6736(99)02816-0.


We describe a hereditary form of alopecia in an aboriginal Finno-Ugric population. Linkage and mutation analyses of 21 families showed that the disorder was not linked to the hairless gene on chromosome 8. This implies that an isolated hairless defect caused by a single gene is a genetically heterogeneous disorder in human populations.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Alopecia / genetics*
  • Child
  • Child, Preschool
  • Ethnicity
  • Female
  • Genetics, Population
  • Humans
  • Infant
  • Male
  • Mutation, Missense
  • Pedigree
  • Russia