Corneal wound healing following laser in situ keratomileusis (LASIK): a histopathological study in rabbits

Br J Ophthalmol. 1999 Nov;83(11):1302-5. doi: 10.1136/bjo.83.11.1302.


Aims: To investigate the histopathological changes of rabbit corneas after laser in situ keratomileusis (LASIK) and to evaluate the corneal wound healing process.

Methods: A LASIK was performed on white rabbit eyes. Postoperatively, rabbits were killed on days 1 and 7, and at 1, 3, and 9 months.

Results: Periodic acid Schiff (PAS) positive material and disorganised collagen fibre were seen along the interface of the corneal flap even 9 months after operation.

Conclusions: The wound healing process still continued at 9 months after LASIK indicating that a much longer time than expected was required for corneal wound healing following LASIK.

MeSH terms

  • Animals
  • Collagen / analysis
  • Cornea / chemistry
  • Cornea / physiopathology*
  • Cornea / surgery*
  • Immunohistochemistry
  • Keratomileusis, Laser In Situ*
  • Rabbits
  • Time Factors
  • Wound Healing*


  • Collagen