Overdose of Rogaine Extra Strength for Men topical minoxidil preparation

J Toxicol Clin Toxicol. 1999;37(6):781-3. doi: 10.1081/clt-100102457.


Minoxidil is a potent arterial vasodilator used in the treatment of hypertension. A side effect, hypertrichosis, has prompted the marketing of a topical preparation, Rogaine, for the treatment of male-pattern baldness. Recently, a 5% solution of minoxidil became available over-the-counter as Rogaine Extra Strength For Men Hair Regrowth Treatment. We describe an oral overdose of minoxidil 3 g as the Rogaine Extra Strength preparation. Toxicity manifested as profound hypotension, requiring vasopressor support, intubation, prolonged tachycardia, and fluid overload with pleural effusions, requiring several days of therapy with furosemide. This is the largest reported ingestion of minoxidil and the first reported overdose of the extra strength 5% solution.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adult
  • Drug Overdose / drug therapy
  • Drug Overdose / etiology*
  • Female
  • Furosemide / therapeutic use
  • Humans
  • Hypotension / chemically induced
  • Hypotension / drug therapy
  • Minoxidil / poisoning*
  • Nonprescription Drugs / poisoning*
  • Phenylephrine / therapeutic use
  • Suicide, Attempted*
  • Treatment Outcome
  • Vasodilator Agents / poisoning*


  • Nonprescription Drugs
  • Vasodilator Agents
  • Phenylephrine
  • Minoxidil
  • Furosemide