Cell-substrate interactions and signaling through ILK

Curr Opin Cell Biol. 2000 Apr;12(2):250-6. doi: 10.1016/s0955-0674(99)00083-6.


Interactions between cells and the extracellular matrix (ECM) result in the regulation of cell growth, cell differentiation and cell migration. These interactions are mediated by integrins and growth factor receptors and intracellular effectors that couple these receptors to downstream components are key to the transduction of ECM signals. This review summarizes recent advances in our understanding of signal transduction via integrins, focusing on the role of integrin-linked kinase in some of these pathways. Research into this interesting protein is uncovering novel aspects of coordinated signaling by the ECM and growth factors.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Cell Survival
  • Integrins / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction*


  • Integrins
  • integrin-linked kinase
  • Protein Serine-Threonine Kinases