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. 2000 Jun;10(3):352-7.
doi: 10.1016/s0959-4388(00)00099-4.

LTP Mechanisms: From Silence to Four-Lane Traffic


LTP Mechanisms: From Silence to Four-Lane Traffic

R Malinow et al. Curr Opin Neurobiol. .


Brief periods of strong neuronal activity induce long-lasting changes in synaptic function. This synaptic plasticity is thought to play important roles in learning and memory. One example--long-term potentation in the CA1 region of the hippocampus--has been studied extensively, and conflicting views regarding the underlying mechanisms have emerged. Recent findings, regarding basic properties of synaptic transmission, appear to reconcile these diverging views.

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