LTP mechanisms: from silence to four-lane traffic

Curr Opin Neurobiol. 2000 Jun;10(3):352-7. doi: 10.1016/s0959-4388(00)00099-4.


Brief periods of strong neuronal activity induce long-lasting changes in synaptic function. This synaptic plasticity is thought to play important roles in learning and memory. One example--long-term potentation in the CA1 region of the hippocampus--has been studied extensively, and conflicting views regarding the underlying mechanisms have emerged. Recent findings, regarding basic properties of synaptic transmission, appear to reconcile these diverging views.

Publication types

  • Review

MeSH terms

  • Animals
  • Hippocampus / cytology
  • Hippocampus / physiology*
  • Long-Term Potentiation / physiology*
  • Neurons / physiology*
  • Synapses / physiology*