Randomized controlled trial of nettle sting for treatment of base-of-thumb pain

J R Soc Med. 2000 Jun;93(6):305-9. doi: 10.1177/014107680009300607.


There are numerous published references to use of nettle sting for arthritis pain but no randomized controlled trials have been reported. We conducted a randomized controlled double-blind crossover study in 27 patients with osteoarthritic pain at the base of the thumb or index finger. Patients applied stinging nettle leaf (Urtica dioica) daily for one week to the painful area. The effect of this treatment was compared with that of placebo, white deadnettle leaf (Lamium album), for one week after a five-week washout period. Observations of pain and disability were recorded for the twelve weeks of the study. After one week's treatment with nettle sting, score reductions on both visual analogue scale (pain) and health assessment questionnaire (disability) were significantly greater than with placebo (P = 0.026 and P = 0.0027).

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cross-Over Studies
  • Disability Evaluation
  • Double-Blind Method
  • Female
  • Fingers
  • Humans
  • Magnoliopsida / therapeutic use*
  • Male
  • Middle Aged
  • Osteoarthritis / therapy*
  • Pain Management*
  • Pain Measurement
  • Patient Compliance
  • Phytotherapy*
  • Thumb
  • Treatment Outcome