An open trial of plasma exchange in childhood-onset obsessive-compulsive disorder without poststreptococcal exacerbations

J Am Acad Child Adolesc Psychiatry. 2000 Oct;39(10):1313-5. doi: 10.1097/00004583-200010000-00020.


Patients with childhood-onset obsessive-compulsive disorder (OCD) with symptom exacerbations following streptococcal infections benefit from treatment with plasma exchange. In this study, 5 patients with treatment-refractory OCD without a history of streptococcus-related exacerbations underwent an open 2-week course of therapeutic plasma exchange. Behavioral ratings, completed at baseline and 4 weeks after the initial treatment, included the Clinical Global Impressions Scale and the Yale-Brown Obsessive Compulsive Scale. All 5 patients completed the trial with few side effects, but none showed significant improvement. Plasma exchange does not benefit children and adolescents with OCD who do not have streptococcus-related exacerbations.

Publication types

  • Evaluation Study

MeSH terms

  • Adolescent
  • Child
  • Female
  • Humans
  • Male
  • Obsessive-Compulsive Disorder / therapy*
  • Plasma Exchange*
  • Streptococcal Infections / therapy*
  • Treatment Outcome