Occupational risk factors for renal cell carcinoma in Montreal

Am J Ind Med. 2000 Dec;38(6):609-18. doi: 10.1002/1097-0274(200012)38:6<609::aid-ajim1>3.0.co;2-4.


Background: Little is known about the role of workplace exposures on the risk of renal cell cancer.

Methods: A population-based case-control study was undertaken in Montreal to assess the association between hundreds of occupational circumstances and several cancer sites, including the kidney. A total of 142 male patients with pathologically confirmed renal cell carcinoma, 1900 controls with cancer at other sites and 533 population-based controls were interviewed. Detailed job histories and relevant data on potential confounders were obtained. A group of chemists-hygienists evaluated each job reported and translated them into a history of occupational exposures using a checklist of 294 substances. Multivariate logistic regression models using either population, cancer controls, or a pool of both groups were used to estimate odds ratios.

Results: There were some indications of excess risks among printers, nursery workers (gardening), aircraft mechanics, farmers, and horticulturists, as well as in the following industries: printing-related services, defense services, wholesale trade, and retail trade. Notwithstanding the low precision of many of the odds ratio estimates, the following workplace exposures showed some evidence of excess risk: chromium compounds, chromium (VI) compounds, inorganic acid solutions, styrene-butadiene rubber, ozone, hydrogen sulphide, ultraviolet radiation, hair dust, felt dust, jet fuel engine emissions, jet fuel, aviation gasoline, phosphoric acid and inks.

Conclusions: For most of these associations there exist no, or very little, previous data. Some associations provide suggestive evidence for further studies.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Renal Cell / epidemiology*
  • Case-Control Studies
  • Humans
  • Kidney Neoplasms / epidemiology*
  • Logistic Models
  • Male
  • Middle Aged
  • Occupational Diseases / epidemiology*
  • Occupational Exposure
  • Quebec / epidemiology
  • Risk Factors