Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture

Nat Genet. 2001 Feb;27(2):153-4. doi: 10.1038/84769.


Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormalities, Multiple / veterinary
  • Animals
  • Blastocyst / physiology*
  • Cloning, Organism / veterinary*
  • Congenital Abnormalities / veterinary
  • DNA Methylation
  • Embryonic and Fetal Development
  • Female
  • Genetic Testing
  • Genomic Imprinting
  • Pregnancy
  • Receptor, IGF Type 2 / genetics*
  • Sheep*


  • Receptor, IGF Type 2