A polymorphic microsatellite marker in the human p55 TNF receptor, CD120a

Genes Immun. 2000 Feb;1(3):228-30. doi: 10.1038/sj.gene.6363663.

Abstract

We provide characterization of a highly polymorphic dinucleotide repeat in the human TNF-receptor 1 gene (TNFR1, TNFRp55, CD120a). We have observed 11 alleles at this locus in individuals from the West of Scotland. In a panel of healthy, unrelated individuals from the West of Scotland (n = 143), the overall heterozygosity was 68%, indicating the potential usefulness of these markers in immunogenetic studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Antigens, CD / genetics*
  • Base Sequence
  • DNA / genetics
  • DNA Primers / genetics
  • Dinucleotide Repeats
  • Heterozygote
  • Humans
  • Microsatellite Repeats*
  • Molecular Sequence Data
  • Polymorphism, Genetic*
  • Receptors, Tumor Necrosis Factor / genetics*
  • Receptors, Tumor Necrosis Factor, Type I
  • Scotland

Substances

  • Antigens, CD
  • DNA Primers
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type I
  • DNA