Memory impairment in abstinent MDMA ("Ecstasy") users: a longitudinal investigation

Neurology. 2001 Apr 10;56(7):966-9. doi: 10.1212/wnl.56.7.966.


To examine the neurotoxic potential of continued MDMA ("Ecstasy") use in humans and its functional consequences over the course of 1 year, 15 MDMA users participated in a longitudinal study in which they completed a brief neuropsychological test battery composed mainly of retrospective and prospective memory tasks. Subjects were abstinent for 2 weeks on initial and 1-year testing. Continued use of MDMA was associated with progressive decline in terms of immediate and delayed recall.

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Memory Disorders / chemically induced*
  • Memory Disorders / psychology*
  • N-Methyl-3,4-methylenedioxyamphetamine / adverse effects*
  • Neuropsychological Tests


  • N-Methyl-3,4-methylenedioxyamphetamine