Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur

Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):755-8. doi: 10.1107/s0907444901003134. Epub 2001 Apr 24.


The structure of a tetragonal crystal form of thiostrepton has been solved using the anomalous dispersive effects of five S atoms from high-redundancy data collected to 1.33 A resolution at the Cu Kalpha wavelength. Data measured to 1.02 A resolution with a synchrotron source were used for refinement. Details of the molecular structure, intramolecular and intermolecular interactions are given.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Crystallization
  • Models, Molecular
  • Protein Conformation
  • Sulfur / chemistry*
  • Thiostrepton / chemistry*


  • Anti-Bacterial Agents
  • Sulfur
  • Thiostrepton