[Post-vaccination granuloma due to aluminium hydroxide]

Ann Pathol. 2001 Apr;21(2):149-52.
[Article in French]


Post-vaccination granulomas a well-known reaction due to aluminium adsorbed vaccines. We report three cases of children who developed subcutaneous nodules at the site of a previous injection of Tetracoq*vaccine (tetanus, diphtheria, Bordetella pertussis, poliovirus). Histologically, the lesions were characterized by a necrotizing granulomatous reaction with eosinophilic crystalline material. This material stained positively with the solochrome cyanine stain and was pink-purple. This aluminium stain enabled diagnosis of post-immunization injection-site reaction due to aluminium.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aluminum Hydroxide / adverse effects*
  • Aluminum Hydroxide / analysis
  • Child, Preschool
  • Coloring Agents
  • Crystallization
  • Diphtheria-Tetanus-Pertussis Vaccine / adverse effects
  • Female
  • Granuloma / chemically induced*
  • Granuloma / pathology
  • Humans
  • Infant
  • Male
  • Necrosis
  • Poliovirus Vaccines / adverse effects
  • Vaccines / adverse effects*


  • Coloring Agents
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Poliovirus Vaccines
  • Vaccines
  • Aluminum Hydroxide