The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa

J Ethnopharmacol. 2001 Jun;76(1):45-8. doi: 10.1016/s0378-8741(01)00216-1.


The aqueous extract of Nigella sativa (N. sativa) was investigated for anti-inflammatory, analgesic and antipyretic activities in animal models. The extract has an anti-inflammatory effect demonstrated by its inhibitory effects on Carrageenan induced paw edema. It also produced significant increase in the hot plate reaction time in mice indicating analgesic effect. However, N. sativa crude suspension had no effect on yeast induced pyrexia. This study therefore, supports its use in folk medicine both as analgesic and anti-inflammatory agent and calls for further investigations to elucidate its mechanism of action.

MeSH terms

  • Analgesia*
  • Analysis of Variance
  • Animals
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / therapeutic use*
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Female
  • Male
  • Medicine, Traditional*
  • Mice
  • Plant Oils / isolation & purification
  • Plant Oils / therapeutic use*
  • Rats
  • Saudi Arabia


  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Plant Oils
  • caraway oil