Snake toxins that bind specifically to individual subtypes of muscarinic receptors

Life Sci. 2001 Apr 27;68(22-23):2541-7. doi: 10.1016/s0024-3205(01)01050-5.

Abstract

This paper discusses the properties of the three most specific ligands found for the extracellular faces of M1, M2 and M4 muscarinic receptors (m1-toxin1, m2-toxin and m4-toxin, respectively). The primary goal of this paper is to show the known and potential usefulness of these toxins and their biotinylated, radioactive, fluorescent and mutated derivatives.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Elapid Venoms / chemistry
  • Elapid Venoms / metabolism*
  • Elapid Venoms / pharmacology
  • Elapidae / metabolism
  • Humans
  • Molecular Sequence Data
  • Muscarinic Antagonists / chemistry
  • Muscarinic Antagonists / metabolism
  • Muscarinic Antagonists / pharmacology
  • Neurotoxins / chemistry
  • Neurotoxins / metabolism
  • Neurotoxins / pharmacology
  • Protein Binding
  • Receptor, Muscarinic M1
  • Receptor, Muscarinic M2
  • Receptor, Muscarinic M4
  • Receptors, Muscarinic / metabolism*
  • Sequence Alignment

Substances

  • Elapid Venoms
  • Muscarinic Antagonists
  • Neurotoxins
  • Receptor, Muscarinic M1
  • Receptor, Muscarinic M2
  • Receptor, Muscarinic M4
  • Receptors, Muscarinic
  • m1-toxin
  • m2-toxin
  • muscarinic toxin MT4