Modulation of human humoral immune response through orally administered bovine colostrum

FEMS Immunol Med Microbiol. 2001 Aug;31(2):93-6. doi: 10.1111/j.1574-695X.2001.tb00504.x.


Eighteen healthy volunteers were randomized into two treatment groups and consumed liquid prepackaged bovine colostrum whey and placebo for 7 days. On days 1, 3 and 5, an attenuated Salmonella typhi Ty21a oral vaccine was given to all subjects to mimic an enteropathogenic infection. The circulating antibody secreting cells and the expression of phagocytosis receptors of the subjects before and after oral immunization were measured with the ELISPOT assay and flow cytometry. All subjects responded well to the vaccine. No significant differences were observed in ELISPOT values for IgA, IgG, IgM, Fcgamma and CR receptor expression on neutrophils and monocytes between the two groups. There was a trend towards greater increase in specific IgA among the subjects receiving their vaccine with bovine colostrum. These results suggest that bovine colostrum may possess some potential to enhance human special immune responses.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Animals
  • Antibodies, Bacterial / biosynthesis
  • Antibodies, Bacterial / immunology*
  • Cattle
  • Colostrum / immunology*
  • Female
  • Humans
  • Immunoglobulins / biosynthesis
  • Immunoglobulins / immunology*
  • Male
  • Middle Aged
  • Milk Proteins / immunology
  • Receptors, Complement / metabolism
  • Receptors, IgG / metabolism
  • Salmonella Vaccines / administration & dosage
  • Salmonella Vaccines / immunology*
  • Salmonella typhi / immunology*
  • Vaccination
  • Whey Proteins


  • Antibodies, Bacterial
  • Immunoglobulins
  • Milk Proteins
  • Receptors, Complement
  • Receptors, IgG
  • Salmonella Vaccines
  • Whey Proteins