Accelerated telomere shortening in Fanconi anemia fibroblasts--a longitudinal study

FEBS Lett. 2001 Sep 28;506(1):22-6. doi: 10.1016/s0014-5793(01)02869-1.


Fanconi anemia (FA) is a fatal inherited disease displaying chromosomal instability, disturbances in oxygen metabolism and a high burden of intracellular radical oxygen species. Oxygen radicals can damage DNA including telomeric regions. Insufficient repair results in single strand breaks that can induce accelerated telomere shortening. In a longitudinal study we demonstrate that telomeric DNA is continuously lost at a higher rate in FA fibroblasts compared to healthy controls. Furthermore, we show that this loss is caused rather by an increased shortening per cell division in regularly replicating cells than by apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Apoptosis
  • Cell Division
  • Cell Line
  • Child
  • DNA Damage
  • Fanconi Anemia / genetics*
  • Fanconi Anemia / pathology
  • Female
  • Humans
  • Infant
  • Longitudinal Studies
  • Male
  • Oxidative Stress
  • Telomere*