Putting the stress on senescence

Curr Opin Cell Biol. 2001 Dec;13(6):748-53. doi: 10.1016/s0955-0674(00)00278-7.


Cultivation of primary cells over many generations eventually results in a reproducible loss of proliferative potential that has been termed 'replicative senescence'. Recent work has revealed the heterogeneity of senescence. Importantly, the analysis of the various aspects and types of senescence has turned out to be very informative about numerous in vivo processes, and particularly about carcinogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cellular Senescence*
  • DNA Damage
  • Humans
  • Mice
  • Models, Biological
  • Oxidative Stress
  • Proto-Oncogene Proteins p21(ras) / physiology
  • Telomere / physiology
  • Transcription, Genetic


  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)