Neonatal Netw. 2000 Dec;19(8):65-7. doi: 10.1891/0730-0832.19.8.65.


The nurse administering any BZD--especially lorazepam--to a neonate must be knowledgeable about the drug's effects and risks and must remember that BZDs do not provide analgesia. The sedative effects of lorazepam will increase with concomitant use of opioids. The nurse must be alert for adverse reactions (Table 1). Close monitoring of the neonate's respiratory effort and blood pressure is important. Because of the various reported cases of myoclonus in neonates after lorazepam administration, close observation for seizure activity is imperative. Although lorazepam use may be beneficial in specific instances, administration should be approached with caution in the neonate (especially in the preterm neonate) and other agents considered.

Publication types

  • Editorial

MeSH terms

  • Anti-Anxiety Agents / administration & dosage*
  • Anti-Anxiety Agents / adverse effects
  • Anxiety / drug therapy
  • Anxiety / prevention & control*
  • Asphyxia Neonatorum / drug therapy
  • Asphyxia Neonatorum / nursing
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Infant, Newborn
  • Intensive Care Units, Neonatal
  • Lorazepam / administration & dosage*
  • Lorazepam / adverse effects
  • Male
  • Neonatal Nursing / methods
  • Risk Assessment
  • Seizures / drug therapy
  • Seizures / nursing
  • Sensitivity and Specificity


  • Anti-Anxiety Agents
  • Lorazepam