The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?

Nat Rev Immunol. 2002 Apr;2(4):283-91. doi: 10.1038/nri779.


The rationale for developing anti-HIV vaccines that stimulate cytotoxic T-lymphocyte responses is given. We argue that such vaccines will work, provided that attention is paid to the development of memory T-cell responses that are strong and preferably activated. Furthermore, the vaccine should match the prevailing virus clade as closely as possible. Vaccines will have to stimulate a wide range of responses, but it is not clear how this can be achieved.

Publication types

  • Review

MeSH terms

  • AIDS Vaccines / immunology*
  • Acquired Immunodeficiency Syndrome / immunology*
  • Acquired Immunodeficiency Syndrome / virology
  • Animals
  • CD8-Positive T-Lymphocytes / immunology*
  • Cytotoxicity, Immunologic*
  • HIV* / genetics
  • HIV* / immunology
  • Humans


  • AIDS Vaccines