In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)

Int J Mol Med. 2002 Jun;9(6):591-5.


An E3B1/Abi2/Argbp1/NESH protein family has recently emerged from analysis of the sequence and structural similarities. These are adaptor proteins possessing homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain that interact with Abl-family tyrosine kinases. Some of the members of this family are involved in cytoskeletal reorganization that plays important roles in membrane-ruffling, lamellipodia formation and cell migration. Furthermore, it seems likely that this family may also regulate cancer development through modulation of the oncogenic Abl kinase. The knowledge of this status is helpful in thinking of the regulatory mechanisms to cell metastasis and to malignant transformation of cancer. We discuss how these interesting molecules work and consider their involvement in cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins / genetics*
  • Cytoskeletal Proteins
  • Humans
  • Models, Biological
  • Models, Genetic
  • Molecular Sequence Data
  • Neoplasms / metabolism
  • Phosphoprotein Phosphatases / genetics*
  • Protein Structure, Tertiary
  • Sequence Homology, Amino Acid
  • src Homology Domains


  • ABI1 protein, human
  • ABI2 protein, human
  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Cytoskeletal Proteins
  • ABI2 protein, Arabidopsis
  • Phosphoprotein Phosphatases