Toxicity of adipic acid

Drug Chem Toxicol. 2002 May;25(2):191-202. doi: 10.1081/dct-120003259.


Adipic acid has very low acute toxicity in rats with an LD50 > 5000 mg/kg. Adipic acid produced mild to no skin irritation on intact guinea pig skin as a 50% concentration in propylene glycol; it was not a skin sensitizer. Adipic acid caused mild conjunctival irritation in washed rabbit eyes; in unwashed rabbit eyes, there was mild conjunctival irritation, minimal iritis, but no corneal effects. Adipic acid dust may irritate the mucous membranes of the lungs and nose. In a 2-year feeding study, rats fed adipic acid at concentrations up to 5% in the diet exhibited only weight loss. Adipic acid is not genetically active in a wide variety of assay systems. Adipic acid caused no developmental toxicity in mice, rats, rabbits, or hamsters when administered orally. Adipic acid is partially metabolized in humans; the balance is eliminated unchanged in the urine. Adipic acid is slightly to moderately toxic to fish, daphnia, and algae in acute tests.

Publication types

  • Review

MeSH terms

  • Adipates / metabolism
  • Adipates / toxicity*
  • Animals
  • Dose-Response Relationship, Drug
  • Ecosystem
  • Environmental Pollutants / toxicity
  • Food Additives / toxicity*
  • Guinea Pigs
  • Humans
  • Mice
  • Occupational Exposure*
  • Rabbits
  • Rats
  • Toxicity Tests*


  • Adipates
  • Environmental Pollutants
  • Food Additives
  • adipic acid