Abstract
Although initially identified in the suppressor of cytokine signaling (SOCS) family of proteins, the C-terminal SOCS box has now been identified in more than 40 proteins in nine different families. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS proteins regulate protein turnover by targeting proteins for polyubiquitination and, therefore, for proteasome-mediated degradation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Carrier Proteins / chemistry
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Carrier Proteins / genetics*
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Carrier Proteins / metabolism*
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Cytokines / metabolism*
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Intracellular Signaling Peptides and Proteins*
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Ligases / metabolism
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Models, Biological
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Molecular Sequence Data
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Protein Structure, Tertiary
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Repressor Proteins*
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Sequence Alignment
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Signal Transduction / physiology*
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Suppressor of Cytokine Signaling 1 Protein
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Suppressor of Cytokine Signaling Proteins
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Ubiquitin-Protein Ligases
Substances
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Carrier Proteins
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Cytokines
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Intracellular Signaling Peptides and Proteins
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Repressor Proteins
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SOCS1 protein, human
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Suppressor of Cytokine Signaling 1 Protein
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Suppressor of Cytokine Signaling Proteins
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Ubiquitin-Protein Ligases
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Ligases