Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span

Antioxid Redox Signal. 2002 Aug;4(4):693-6. doi: 10.1089/15230860260220201.


Transgenic (Tg) mice overexpressing human thioredoxin (TRX), a small redox-active protein, were produced to investigate the role of the protein in a variety of stresses. Bone marrow cells from TRX-Tg mice were more resistant to ultraviolet C-induced cytocide compared with those from wild type (WT) C57BL/6 mice. TRX-Tg mice exhibited extended median and maximum life spans compared with WT mice. Telomerase activity in spleen tissues in TRX-Tg mice was higher than that in WT mice. These results suggest that overexpression of TRX results in resistance against oxidative stress and a possible extension of life span without apparent abnormality in mammals.

MeSH terms

  • Animals
  • Bone Marrow Cells / metabolism
  • Bone Marrow Cells / radiation effects
  • Brain / metabolism
  • Humans
  • Longevity*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Myocardium / metabolism
  • Oxidative Stress*
  • Spleen / enzymology
  • Survival Rate
  • Telomerase / metabolism
  • Thioredoxins / genetics*
  • Thioredoxins / metabolism*
  • Ultraviolet Rays


  • Thioredoxins
  • Telomerase