Imaging single mammalian cells with a 1.5 T clinical MRI scanner

Magn Reson Med. 2003 May;49(5):968-71. doi: 10.1002/mrm.10417.

Abstract

In the present work, we demonstrate that the steady-state free precession (SSFP) imaging pulse sequence FIESTA (fast imaging employing steady state acquisition) used in conjunction with a custom-built insertable gradient coil and customized RF coils can be used to detect individual SPIO-labeled cells using a commonly available 1.5 T clinical MRI scanner. This work provides the first evidence that single-cell tracking will be possible using clinical MRI scanners, opening up new possibilities for cell tracking and monitoring of cellular therapeutics in vivo in humans.

MeSH terms

  • Cell Separation / methods
  • Ferric Compounds
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Tumor Cells, Cultured

Substances

  • Ferric Compounds
  • ferric oxide