Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble

Trends Biochem Sci. 2003 Jun;28(6):313-20. doi: 10.1016/s0968-0004(03)00112-9.


Integrins are one of the major families of cell-adhesion receptors. In the past year, the first structure of an integrin has been published, ligand-binding pockets have been defined, and mechanisms of receptor priming and activation elucidated. Like all major advances, however, these studies have raised more questions than they have answered about issues such as the mechanisms underlying ligand-binding specificity and long-range conformational regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Adhesion
  • Cell Adhesion Molecules / chemistry
  • Integrins / chemistry
  • Integrins / physiology*
  • Ligands
  • Models, Molecular
  • Protein Binding
  • Protein Conformation
  • Signal Transduction


  • Cell Adhesion Molecules
  • Integrins
  • Ligands