A tale of timing and transport

Neuron. 2003 Aug 28;39(5):729-30. doi: 10.1016/s0896-6273(03)00528-2.


Excitatory and inhibitory synapses show long-term plasticity, but spike timing-dependent plasticity was seen only at excitatory connections. No longer. In this issue of Neuron, Woodin et al. demonstrate that coincident pre- and postsynaptic activity acts on the neuronal K+/Cl- cotransporter KCC2 to shift the reversal potential for Cl- and thus alters the effectiveness of GABAergic synapses.

Publication types

  • Comment
  • Review

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Excitatory Postsynaptic Potentials / physiology
  • K Cl- Cotransporters
  • Neuronal Plasticity / physiology*
  • Neurons / physiology*
  • Symporters / physiology*
  • Synapses / physiology*
  • gamma-Aminobutyric Acid / metabolism


  • Symporters
  • gamma-Aminobutyric Acid