A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne

Australas J Dermatol. 1992;33(3):131-4. doi: 10.1111/j.1440-0960.1992.tb00100.x.


Alpha hydroxy acids (AHA's) or "fruit acids" are a special group of organic acids found in many natural foods. They have been described in the literature for the treatment of a number of conditions in which abnormal keratinization consistently contributes to pathogenesis. These include the icthyoses, warts, psoriasis, eczema and acne. We have performed a double-blind clinical trial on 150 patients to evaluate the efficacy and skin tolerance of the alpha hydroxy acid gluconolactone 14% in solution (Nuvoderm lotion) in the treatment of mild to moderate acne when compared with its vehicle (placebo) and 5% benzoyl peroxide lotion. The results of this study showed that both gluconolactone and benzoyl peroxide had a significant effect in improving patients' acne by reducing the number of lesions (inflamed and non-inflamed). Furthermore, fewer side-effects were experienced by patients treated with gluconolactone when compared with benzoyl peroxide.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Acne Vulgaris / pathology
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Benzoyl Peroxide / administration & dosage
  • Benzoyl Peroxide / adverse effects
  • Benzoyl Peroxide / therapeutic use*
  • Double-Blind Method
  • Female
  • Gluconates / administration & dosage
  • Gluconates / adverse effects
  • Gluconates / therapeutic use*
  • Humans
  • Lactones
  • Male
  • Placebos
  • Prospective Studies
  • Skin / drug effects
  • Skin / pathology
  • Skin Diseases / chemically induced
  • Time Factors


  • Gluconates
  • Lactones
  • Placebos
  • Benzoyl Peroxide
  • beta-glucono-1,5-lactone