Clinical and pharmacokinetic effects of a diet rich in insoluble fiber on Parkinson disease

Clin Neuropharmacol. 1992 Oct;15(5):375-80. doi: 10.1097/00002826-199210000-00004.


In this study, the effects of a diet rich in insoluble fiber (DRIF) on motor disability and the peripheral pharmacokinetics of orally administered L-dopa in Parkinsonian patients with marked constipation are analyzed. We found a useful effect of a DRIF on plasma L-dopa concentration and motor function. The greatest effect on the plasma L-dopa levels was found early (at 30 and 60 min) after oral administration. There was a relationship between the improvement of constipation and the higher bioavailability of L-dopa. DRIF can be a coadjuvant treatment in patients with Parkinson's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Aged
  • Constipation / drug therapy
  • Dietary Fiber / pharmacology*
  • Female
  • Gastrointestinal Motility / drug effects
  • Humans
  • Intestinal Absorption / drug effects
  • Levodopa / administration & dosage
  • Levodopa / adverse effects
  • Levodopa / pharmacokinetics
  • Male
  • Motor Activity / drug effects
  • Movement Disorders / drug therapy
  • Parkinson Disease / drug therapy
  • Parkinson Disease / metabolism
  • Parkinson Disease / physiopathology*
  • Psychomotor Performance / drug effects
  • Time Factors


  • Dietary Fiber
  • Levodopa