Stopping smoking can cause constipation

Addiction. 2003 Nov;98(11):1563-7. doi: 10.1046/j.1360-0443.2003.00497.x.


Setting: Constipation is mentioned occasionally as a possible tobacco withdrawal symptom, but no systematic data have been published on this issue.

Design: Smokers' clinic patients provided ratings of their level of constipation on three occasions prior to their quit date, and then weekly after they stopped smoking. The total of 1067 participants maintained at least 1 week of continuous abstinence and provided usable data.

Findings: The three precessation ratings of constipation were stable. After cessation of smoking, the ratings increased significantly (P < 0.01). In 514 patients who maintained continuous abstinence for 4 weeks and provided complete data, constipation peaked at 2 weeks but remained elevated over the whole period. The net proportion of patients affected was 17%, including 9% who were symptom-free at baseline and became very or extremely constipated. In patients on nicotine replacement the increase in constipation, although significant, was less than in patients on bupropion.

Conclusions: Clinicians treating smokers need to be aware of a possibility that one in six quitters develop constipation, and that for about one in 11 the problem can be severe. Descriptions of tobacco withdrawal syndrome should include constipation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bupropion / therapeutic use
  • Constipation / etiology*
  • Dopamine Uptake Inhibitors / therapeutic use
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nicotine / therapeutic use
  • Psychiatric Status Rating Scales
  • Smoking / adverse effects*
  • Smoking Cessation*
  • Substance Withdrawal Syndrome / drug therapy
  • Substance Withdrawal Syndrome / etiology*


  • Dopamine Uptake Inhibitors
  • Bupropion
  • Nicotine