Mitotic mechanics: the auroras come into view

Curr Opin Cell Biol. 2003 Dec;15(6):672-83. doi: 10.1016/


Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.

Publication types

  • Review

MeSH terms

  • Animals
  • Aurora Kinase B
  • Aurora Kinases
  • Cell Cycle Proteins
  • Cell Division
  • Chromatids / chemistry
  • Chromatin / metabolism
  • Drosophila
  • Glycogen Debranching Enzyme System / chemistry
  • Humans
  • Kinetics
  • Microscopy, Fluorescence
  • Microtubules
  • Mitosis*
  • Models, Biological
  • Protein Kinases / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • Xenopus
  • Xenopus Proteins


  • Cell Cycle Proteins
  • Chromatin
  • Glycogen Debranching Enzyme System
  • Xenopus Proteins
  • 4 alpha-glucanotransferase
  • Protein Kinases
  • AURKA protein, Xenopus
  • AURKB protein, human
  • Aurora Kinase B
  • Aurora Kinases
  • Protein Serine-Threonine Kinases